SeaChem Cupramine is superior to copper sulfate, chloride and citrate: it is non-acidic, less toxic to fish, remains in solution, and does not contaminate the filter bed. Seachem Cupramine is superior to traditional chelates: it is fully charged (ionic), active at low concentrations, and is can be removed from your water with carbon. Buffered active copper For marine or freshwater Less toxic, superior to and safer than copper chlorides, sulfates, citrates and chelates